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Retatrutide in Phase 2 used weekly subcutaneous injections starting at 2 mg, escalating through 4 mg and 8 mg to 12 mg over approximately 24 weeks

doi: 10.1038/s41586-020-2918-0 206 ObayanA

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This conformation causes retatrutide to straighten, shifting its tip towards the TMD core by 4.29 and 4.13 (measured by the C of L27 P ), relative to GLP-1R and GCGR, respectively

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